The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter.

@article{Procko2009TheMO,
  title={The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter.},
  author={Erik Procko and Megan L. O'Mara and W. F. Drew Bennett and D. Peter Tieleman and Rachelle Gaudet},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2009},
  volume={23 5},
  pages={1287-302}
}
The shuttling of substrates across a cellular membrane frequently requires a specialized ATP-binding cassette (ABC) transporter, which couples the energy of ATP binding and hydrolysis to substrate transport. Due to its importance in immunity, the ABC transporter associated with antigen processing (TAP) has been studied extensively and is an excellent model for other ABC transporters. The TAP protein pumps cytosolic peptides into the endoplasmic reticulum for loading onto class I major… CONTINUE READING
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