Corpus ID: 20864840

The mechanism for the inhibition of prostaglandin H synthase-catalyzed xenobiotic oxidation by methimazole. Reaction with free radical oxidation products.

@article{Petry1987TheMF,
  title={The mechanism for the inhibition of prostaglandin H synthase-catalyzed xenobiotic oxidation by methimazole. Reaction with free radical oxidation products.},
  author={T W Petry and Thomas E. Eling},
  journal={The Journal of biological chemistry},
  year={1987},
  volume={262 29},
  pages={
          14112-8
        }
}
  • T W Petry, Thomas E. Eling
  • Published 1987
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • Methimazole, an irreversible, mechanism-based (suicide substrate) inhibitor of thyroid peroxidase and lactoperoxidase, also inhibits the oxidation of xenobiotics by prostaglandin hydroperoxidase. The mechanism(s) by which methimazole inhibits prostaglandin H synthase-catalyzed oxidations is not conclusively known. In studies reported here, methimazole inhibited the prostaglandin H synthase-catalyzed oxidation of benzidine, phenylbutazone, and aminopyrine in a concentration-dependent manner… CONTINUE READING

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