The mechanism by which the selective 5-HT1A receptor antagonist S-(−)UH 301 produces head-twitches in mice

@article{Darmani1996TheMB,
  title={The mechanism by which the selective 5-HT1A receptor antagonist S-(−)UH 301 produces head-twitches in mice},
  author={Nissar A. Darmani and Sharon L. Reeves},
  journal={Pharmacology Biochemistry and Behavior},
  year={1996},
  volume={55},
  pages={1-10}
}

The silent and selective 5-HT1A antagonist, WAY 100635, produces via an indirect mechanism, a 5-HT2A receptor-mediated behaviour in mice during the day but not at night

  • N. Darmani
  • Biology
    Journal of Neural Transmission
  • 1998
It appears that WAY 100635 produces the HTR indirectly via disinhibition of endogenous serotonergic inhibitory tone operating on the somatodenritic pulse-modulating 5-HT1A autoreceptors, which subsequently stimulates postsynaptic 5- HT2A receptors to produce the head-twitch behaviour.

Role of 5-HT2A, 5-HT2C, 5-HT1A and TAAR1 Receptors in the Head Twitch Response Induced by 5-Hydroxytryptophan and Psilocybin: Translational Implications

The key role of 5-HT2AR is confirmed in in the induction of HTR by5-HTP and psilocybin, and the effect of a 5- HT1AR agonist to attenuate HTR and a bimodal contribution of 5 -HT2CR as well as a role of TAAR1 in modulating HTR induced by 5-htP are confirmed.

Cannabinoid-induced enhanced interaction and protein levels of serotonin 5-HT2A and dopamine D2 receptors in rat prefrontal cortex

Positive experimental evidence is presented that Sprague-Dawley rats treated with a non-selective cannabinoid receptor agonist showed enhanced co-immunoprecipitation of 5-HT2A and D2 receptors and enhanced membrane-associated expression of D2 and 5- HT2A receptors in prefrontal cortex (PFCx), suggesting a cannabinoid-induced upregulation of5-HT 2A receptors.

5-HT1AReceptors Modulate the Consolidation of Learning in Normal and Cognitively Impaired Rats

Data confirm a role for presynaptic 5-HT1A receptors during the consolidation of learning and support the hypothesis that serotonergic, cholinergic, and glutamatergic systems interact in cognitively impaired animals.

The 5-HT1A receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats

It is suggested that 5-HT1A signaling is involved in sensory inhibition and support the evaluation of 5- HT1A receptor active compounds in conditions with central filtering deficits, such as schizophrenia.

Evidence for functional interactions between 5-HT1A and 5-HT2A receptors in rat thermoregulatory mechanisms.

The present results provide evidence for functional interactions between 5-HT1A and 5- HT2A receptors in temperature regulation in rats, and also suggest an important role for postsynaptic 4-HT2A/C receptors in the mediation of DOI-induced hyperthermia.

Pharmacological characterization of JNJ-28583867, a histamine H(3) receptor antagonist and serotonin reuptake inhibitor.

Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens

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