The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes.

@article{Obrig1971TheMB,
  title={The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes.},
  author={Tom G. Obrig and W J Culp and Wallace L. Mckeehan and B. Hardesty},
  journal={The Journal of biological chemistry},
  year={1971},
  volume={246 1},
  pages={174-81}
}
Cycloheximide and related glutarimide antibiotics have been shown to affect binding, transfer enzyme II-dependent movement, and release of transfer RNA from the donor site of reticulocyte ribosomes, as well as both the initiation and extension of globin and phenylalanine peptides. They inhibit binding of deacylated tRNAPhe to reticulocyte ribosomes in the… CONTINUE READING