The mechanism, function and regulation of depolymerizing kinesins during mitosis.

@article{Moore2004TheMF,
  title={The mechanism, function and regulation of depolymerizing kinesins during mitosis.},
  author={Ayana T. Moore and Linda Wordeman},
  journal={Trends in cell biology},
  year={2004},
  volume={14 10},
  pages={537-46}
}
Kinesins are motor proteins that use the hydrolysis of ATP to do mechanical work. Most of these motors translocate cargo along the surface of the microtubule (MT). However, a subfamily of these motors (Kin-I kinesins) can destabilize MTs directly from their ends. This distinct ability makes their activity crucial during mitosis, when reordering of the MT cytoskeleton is most evident. Recently, much work has been done to elucidate the structure and mechanism of depolymerizing kinesins… CONTINUE READING