The mechanically active domain of titin in cardiac muscle.

  title={The mechanically active domain of titin in cardiac muscle.},
  author={K{\'a}roly Trombit{\'a}s and Jungeun Jin and Henk L. M. Granzier},
  journal={Circulation research},
  volume={77 4},
One of the main contributors to passive tension of the myocardium is titin. However, it is not exactly known what portions of this approximately 1 micron-long molecule are anchored in the sarcomere (hence, are rendered inelastic) and what portions are elastic (hence, are mechanically active in developing passive tension). We assessed the length of the elastic domain of cardiac titin by ultrastructural and mechanical methods. Single cardiac myocytes were stretched by various amounts, and while… CONTINUE READING

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