The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells.

Abstract

Glioblastoma multiforme (GBM) is a malignant astrocytoma of the central nervous system associated with a median survival time of 15 months, even with aggressive therapy. This rapid progression is due in part to diffuse infiltration of single tumor cells into the brain parenchyma, which is thought to involve aberrant interactions between tumor cells and the… (More)
DOI: 10.1158/0008-5472.CAN-08-4859

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@article{Ulrich2009TheMR, title={The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells.}, author={Theresa A. Ulrich and Elena M de Juan Pardo and Sanjay Kumar}, journal={Cancer research}, year={2009}, volume={69 10}, pages={4167-74} }