The mechanical memory of lung myofibroblasts.

  title={The mechanical memory of lung myofibroblasts.},
  author={Jenna Leigh Balestrini and Sidharth Chaudhry and Vincent Sarrazy and Anne B. Koehler and Boris Hinz},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  volume={4 4},
Fibroblasts differentiate into the highly synthetic and contractile myofibroblast phenotype when exposed to substrates with an elastic modulus corresponding to pathologically stiff fibrotic tissue. Cellular responses to changes in substrate stiffness are typically analyzed after hours or days, which does not enable the monitoring of myofibroblast persistence, a hallmark of fibrosis. To determine long-lasting effects on the fibrotic behavior of lung fibroblasts, we followed a novel approach of… CONTINUE READING

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