• Corpus ID: 40700426

The mechanical design of spider silks: from fibroin sequence to mechanical function.

@article{Gosline1999TheMD,
  title={The mechanical design of spider silks: from fibroin sequence to mechanical function.},
  author={John M. Gosline and Paul A. Guerette and Christine Ortlepp and Ken N. Savage},
  journal={The Journal of experimental biology},
  year={1999},
  volume={202 Pt 23},
  pages={
          3295-303
        }
}
Spiders produce a variety of silks, and the cloning of genes for silk fibroins reveals a clear link between protein sequence and structure-property relationships. The fibroins produced in the spider's major ampullate (MA) gland, which forms the dragline and web frame, contain multiple repeats of motifs that include an 8-10 residue long poly-alanine block and a 24-35 residue long glycine-rich block. When fibroins are spun into fibres, the poly-alanine blocks form (&bgr;)-sheet crystals that… 

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