The mechanical activation of mTOR signaling: an emerging role for late endosome/lysosomal targeting

  title={The mechanical activation of mTOR signaling: an emerging role for late endosome/lysosomal targeting},
  author={Brittany L. Jacobs and Craig A Goodman and Troy A Hornberger},
  journal={Journal of Muscle Research and Cell Motility},
It is well recognized that mechanical signals play a critical role in the regulation of skeletal muscle mass, and the maintenance of muscle mass is essential for mobility, disease prevention and quality of life. Furthermore, over the last 15 years it has become established that signaling through a protein kinase called the mammalian (or mechanistic) target of rapamycin (mTOR) is essential for mechanically-induced changes in protein synthesis and muscle mass, however, the mechanism(s) via which… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 100 references

Lysosomes: fusion and function

Nature Reviews Molecular Cell Biology • 2007
View 12 Excerpts
Highly Influenced

Endosome acidification and the pathways of receptor-mediated endocytosis.

Advances in experimental medicine and biology • 1987
View 8 Excerpts
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Mechanotransduction and the regulation of mTORC1 signaling in skeletal muscle.

The international journal of biochemistry & cell biology • 2011
View 5 Excerpts
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