The mec-8 gene of C. elegans encodes a protein with two RNA recognition motifs and regulates alternative splicing of unc-52 transcripts.

@article{Lundquist1996TheMG,
  title={The mec-8 gene of C. elegans encodes a protein with two RNA recognition motifs and regulates alternative splicing of unc-52 transcripts.},
  author={Erik A Lundquist and Robert K. Herman and Teresa M. Rogalski and Gregory P. Mullen and Donald G. Moerman and Jocelyn E. Shaw},
  journal={Development},
  year={1996},
  volume={122 5},
  pages={1601-10}
}
Mutations in the mec-8 gene of Caenorhabditis elegans were previously shown to affect the functions of body wall muscle and mechanosensory and chemosensory neurons. Mutations in mec-8 also strongly enhance the mutant phenotype of specific mutations in unc-52, a gene that encodes, via alternative splicing of pre-mRNA, a set of basement membrane proteins, homologs of perlecan, that are important for body wall muscle assembly and attachment to basement membrane, hypodermis and cuticle. We have… CONTINUE READING
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