The measurement of synaptic delay, and the time course of acetylcholine release at the neuromuscular junction

@article{Katz1965TheMO,
  title={The measurement of synaptic delay, and the time course of acetylcholine release at the neuromuscular junction},
  author={Bernard Katz and Ricardo Miledi},
  journal={Proceedings of the Royal Society of London. Series B. Biological Sciences},
  year={1965},
  volume={161},
  pages={483 - 495}
}
  • B. Katz, R. Miledi
  • Published 16 February 1965
  • Chemistry, Medicine
  • Proceedings of the Royal Society of London. Series B. Biological Sciences
Focal recording from active spots of a neuromuscular junction was used to measure the ‘synaptic delay’ between terminal axon spike and end-plate current (e.p.c.). Synaptic delay is defined as the time interval between peak of inward current through the presynaptic membrane and commencement of inward current through the postsynaptic membrane. By substituting magnesium for calcium in the medium, and by adjustable electrophoretic application of calcium from the recording electrode, the e.p.c. can… Expand

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  • Proceedings of the Royal Society of London. Series B. Biological Sciences
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The method of external focal recording from the neuromuscular junction has been used and it is concluded that the action of calcium is concerned directly with the release of the transmitter, and not indirectly by facilitating propagation or increasing the amplitude of the terminal nerve spike. Expand
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