The measurement and distribution of carnosine in the rat.

  title={The measurement and distribution of carnosine in the rat.},
  author={William J. Reddy and D. Mark Hegsted},
  journal={The Journal of biological chemistry},
Preparation of Tissue Extra&+-Adult male rats of the SpragueDawley strain, fed Purina chow ad libitum, were killed with ether. The thigh muscles, or other tissues, were sliced finely, obvious fat and connective tissues having been discarded, and a 1 g portion was transferred to a large test tube. The tissue was extracted twice with 10 ml of water by placing the tube in a water bath at 100” for 10 minutes. The extracts were decanted through a filter into a 25-ml volumetric flask, and the… Expand
Anti-Stress Effects of Carnosine on Restraint-Evoked Immunocompromise in Mice through Spleen Lymphocyte Number Maintenance
It is suggested that the maintenance of spleen lymphocyte number by carnosine was related with the inhibition of lymphocytes apoptosis caused by glucocorticoids overflow and stimulating lymphocyte proliferation, thus prevented immunocompromise in restraint-stressed mice. Expand
Carnosine ameliorates stress-induced glucose metabolism disorder in restrained mice.
The results showed that restraint stress could significantly influence glucose metabolism, as reflected by lowered glucose tolerance, hepatic and muscle glycogen content, and increased plasma corticosterone concentration in mice. Expand
Carnosine Modulates Stress-Attenuated Plasma Antioxidative Capacity
Oral administration of carnosine (β-alanyl-L-histidine) in mice treated with restraint stress moderately alleviated a stress-induced decrease in plasma oxygen radical absorbance capacity (ORAC)Expand