The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.

@article{Finlay1993TheMO,
  title={The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.},
  author={Cathy A. Finlay},
  journal={Molecular and cellular biology},
  year={1993},
  volume={13 1},
  pages={301-6}
}
Expression of a p53-associated protein, Mdm-2 (murine double minute-2), can inhibit p53-mediated transactivation. In this study, overexpression of the Mdm-2 protein was found to result in the immortalization of primary rat embryo fibroblasts (REFs) and, in conjunction with an activated ras gene, in the transformation of REFs. The effect of wild-type p53 on the transforming properties of mdm-2 was determined by transfecting REFs with ras, mdm-2, and normal p53 genes. Transfection with ras plus… CONTINUE READING

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