The maximal cytoprotective function of the heat shock protein 27 is dependent on heat shock protein 70.

@article{Sreedharan2011TheMC,
  title={The maximal cytoprotective function of the heat shock protein 27 is dependent on heat shock protein 70.},
  author={Rajasree Sreedharan and Michael Riordan and G Thullin and Scott Van Why and Norman Joseph Siegel and Michaele Kashgarian},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1813 1},
  pages={129-35}
}
Endogenous heat shock proteins (HSPs) 70 and 25/27 are induced in renal cells by injury from energy depletion. Transfected over-expression of HSPs 70 or 27 (human analogue of HSP25), provide protection against renal cell injury from ATP deprivation. This study examines whether over-expressed HSP27 depends on induction of endogenous HSPs, in particular HSP70, to afford protection against cell injury. LLC-PK1 cells transfected with HSP27 (27OE cells) were injured by ATP depletion for 2h and… CONTINUE READING

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