The maturing immune system: implications for development and testing HIV-1 vaccines for children and adolescents

@article{Jaspan2006TheMI,
  title={The maturing immune system: implications for development and testing HIV-1 vaccines for children and adolescents},
  author={Heather B. Jaspan and Stephen D. Lawn and Jeffrey T. Safrit and Linda-Gail Bekker},
  journal={AIDS},
  year={2006},
  volume={20},
  pages={483–494}
}
Inclusion of children and adolescents in clinical trial research and particularly HIV vaccine trials is difficult. Ethico-legal issues concerning age of informed consent protection of children and reporting of illegal sexual activity and sexually transmitted diseases confront researchers. Socio-behavioral issues include assessment of true understanding of the consent form and possible disinhibition of sexual behaviour whilst participating in trials. There is also a lack of experience in… Expand
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