The matrix corroded: podosomes and invadopodia in extracellular matrix degradation.

  title={The matrix corroded: podosomes and invadopodia in extracellular matrix degradation.},
  author={Stefan Linder},
  journal={Trends in cell biology},
  volume={17 3},
Podosomes and invadopodia are unique actin-rich adhesions that establish close contact to the substratum but can also degrade components of the extracellular matrix. Accordingly, matrix degradation localized at podosomes or invadopodia is thought to contribute to cellular invasiveness in physiological and pathological situations. Cell types that form podosomes include monocytic, endothelial and smooth muscle cells, whereas invadopodia have been mostly observed in carcinoma cells. This review… CONTINUE READING
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