The matricellular protein CCN1 is essential for cardiac development.

  title={The matricellular protein CCN1 is essential for cardiac development.},
  author={Fan-E Mo and Lester F. Lau},
  journal={Circulation research},
  volume={99 9},
The matricellular protein CCN1 (formerly named CYR61) regulates cell adhesion, migration, proliferation, survival, and differentiation through binding to integrin receptors and heparan sulfate proteoglycans. Here we show that Ccn1-null mice are impaired in cardiac valvuloseptal morphogenesis, resulting in severe atrioventricular septal defects (AVSD). Remarkably, haploinsufficiency for Ccn1 also results in delayed formation of the ventricular septum in the embryo and persistent ostium primum… CONTINUE READING


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The angiogenic inducer Cyr61 induces a genetic program for wound healing in human skin fibroblasts

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