The matricellular protein CCN1 controls retinal angiogenesis by targeting VEGF, Src homology 2 domain phosphatase-1 and Notch signaling.

@article{Chintala2015TheMP,
  title={The matricellular protein CCN1 controls retinal angiogenesis by targeting VEGF, Src homology 2 domain phosphatase-1 and Notch signaling.},
  author={Hemabindu Chintala and Izabela Krupska and Lulu Yan and Lester F. Lau and Maria B Grant and Brahim Chaqour},
  journal={Development},
  year={2015},
  volume={142 13},
  pages={2364-74}
}
Physiological angiogenesis depends on the highly coordinated actions of multiple angiogenic regulators. CCN1 is a secreted cysteine-rich and integrin-binding matricellular protein required for proper cardiovascular development. However, our understanding of the cellular origins and activities of this molecule is incomplete. Here, we show that CCN1 is predominantly expressed in angiogenic endothelial cells (ECs) at the leading front of actively growing vessels in the mouse retina. Endothelial… CONTINUE READING