The maternal gene spn-4 encodes a predicted RRM protein required for mitotic spindle orientation and cell fate patterning in early C. elegans embryos.

@article{Gomes2001TheMG,
  title={The maternal gene spn-4 encodes a predicted RRM protein required for mitotic spindle orientation and cell fate patterning in early C. elegans embryos.},
  author={Jos{\'e} Eug{\^e}nio Gomes and Sandra E Encalada and Kathryn A Swan and Christopher A. Shelton and J. Clayton Carter and Bruce Bowerman},
  journal={Development},
  year={2001},
  volume={128 21},
  pages={4301-14}
}
C. elegans embryogenesis begins with a stereotyped sequence of asymmetric cell divisions that are largely responsible for establishing the nematode body plan. These early asymmetries are specified after fertilization by the widely conserved, cortically enriched PAR and PKC-3 proteins, which include three kinases and two PDZ domain proteins. During asymmetric cell divisions in the early embryo, centrosome pairs initially are positioned on transverse axes but then rotate to align with the… CONTINUE READING

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