The mast cell.

  title={The mast cell.},
  author={Dean D Metcalfe and Michael A. Kaliner and Mildred A. Donlon},
  journal={Critical reviews in immunology},
  volume={3 1},
The mast cell is the cellular basis for immediate hypersensitivity reactions. The specificity of the immediate hypersensitivity reaction is attributable to IgE molecules fixed to specific membrane receptors which, when stimulated by specific antigen, initiates the process of degranulation of the mast cell. The granules provide three separate sources of biologic activity: performed or primary mediators, newly generated or secondary mediators, and activities associated with the granular matrix. A… CONTINUE READING