The marine sponge Diacarnus bismarckensis as a source of peroxiterpene inhibitors of Trypanosoma brucei, the causative agent of sleeping sickness.

@article{Rubio2009TheMS,
  title={The marine sponge Diacarnus bismarckensis as a source of peroxiterpene inhibitors of Trypanosoma brucei, the causative agent of sleeping sickness.},
  author={Brent K Rubio and Karen Tenney and K. M. Ang and Maha H Abdulla and Michelle Arkin and James H McKerrow and Phillip Crews},
  journal={Journal of natural products},
  year={2009},
  volume={72 2},
  pages={218-22}
}
Human African trypanosomiasis, also known as African sleeping sickness, is a neglected tropical disease with inadequate therapeutic options. We have launched a collaborative new lead discovery venture using our repository of extracts and natural product compounds as input into our growth inhibition primary screen against Trypanosoma brucei. Careful evaluation of the spectral data of the natural products and derivatives allowed for the elucidation of the absolute configuration (using the… CONTINUE READING
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