The marine natural product adociasulfate-2 as a tool to identify the MT-binding region of kinesins.

@article{Brier2006TheMN,
  title={The marine natural product adociasulfate-2 as a tool to identify the MT-binding region of kinesins.},
  author={S. Brier and E. Carletti and S. Debonis and E. Hewat and D. Lemaire and F. Kozielski},
  journal={Biochemistry},
  year={2006},
  volume={45 51},
  pages={
          15644-53
        }
}
Kinesins are molecular motors that transport cargo along microtubules (MTs). To move forward the motor must attach to the MT in a defined orientation and detach from it in a process that is driven by ATP hydrolysis. The knowledge of the motor-MT interface is essential for a detailed understanding of how kinesins move along MTs and how they are related to other molecular motors such as myosins or dyneins. We have used the marine natural product adociasulfate-2 (AS-2), previously identified as a… Expand
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