The marine alkaloid naamidine A promotes caspase-dependent apoptosis in tumor cells.

@article{LaBarbera2009TheMA,
  title={The marine alkaloid naamidine A promotes caspase-dependent apoptosis in tumor cells.},
  author={Daniel V LaBarbera and Katarzyna Modzelewska and Amanda I Glazar and Phillip D. Gray and Manjinder Kaur and Tong Liu and Douglas Grossman and Mary Kay Harper and Scott K. Kuwada and Nadeem Moghal and Chris M. Ireland},
  journal={Anti-cancer drugs},
  year={2009},
  volume={20 6},
  pages={425-36}
}
Apoptosis is important for normal development and removal of damaged cells. Evasion of apoptosis by cancer cells is one of the key characteristics of many tumor types. Thus, discovering agents that promote apoptosis in tumor cells could have great therapeutic value. Marine natural products have demonstrated great potential as anticancer agents, and the proapoptotic activity of some of these products is emerging as a potentially useful property for cancer treatments. Using a tumor xenograft… CONTINUE READING

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