The many substrates and functions of ATM

@article{Kastan2000TheMS,
  title={The many substrates and functions of ATM},
  author={Michael B. Kastan and Dae-Sik Lim},
  journal={Nature Reviews Molecular Cell Biology},
  year={2000},
  volume={1},
  pages={179-186}
}
  • M. Kastan, D. Lim
  • Published 1 December 2000
  • Biology
  • Nature Reviews Molecular Cell Biology
As its name suggests, the ATM ? 'ataxia-telangiectasia, mutated' ? gene is responsible for the rare disorder ataxia-telangiectasia. Patients show various abnormalities, mainly in their responses to DNA damage, but also in other cellular processes. Although it is hard to understand how a single gene product is involved in so many physiological processes, a clear picture is starting to emerge. 
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Cellular functions of the protein kinase ATM and their relevance to human disease.
TLDR
Recent structural insights into ATM regulation, and possible aetiologies of A-T phenotypes, are discussed, including reactive oxygen species, mitochondrial dysfunction, alterations in transcription, R-loop metabolism and alternative splicing, defects in cellular proteostasis and metabolism, and potential pathogenic roles for hyper-poly(ADP-ribosyl)ation.
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TLDR
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TLDR
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TLDR
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