The many roles of histone deacetylases in development and physiology: implications for disease and therapy

@article{Haberland2009TheMR,
  title={The many roles of histone deacetylases in development and physiology: implications for disease and therapy},
  author={Michael Haberland and Rusty L. Montgomery and Eric N Olson},
  journal={Nature Reviews Genetics},
  year={2009},
  volume={10},
  pages={32-42}
}
Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in numerous biological processes, largely through their repressive influence on transcription. The expression of many HDAC isoforms in eukaryotic cells raises questions about their possible specificity or redundancy, and whether they control global or specific programmes of gene expression. Recent analyses of HDAC knockout mice have revealed highly specific functions of individual HDACs in development and… CONTINUE READING
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