The many roles of cytochrome b5.

  title={The many roles of cytochrome b5.},
  author={John B. Schenkman and Ingela Jansson},
  journal={Pharmacology & therapeutics},
  volume={97 2},
Four distinct suggestions have been made to explain the mechanism of the cytochrome b(5)-imposed positive modifier action of the cytochrome P450 monooxygenase reaction. The first mechanism involves a direct input of an electron into the monooxygenase cycle. This is the second of the two electrons necessary for activation of molecular oxygen, and appears to be a rate-limiting step in the monooxygenase reaction. P450 monooxygenases all appear to be uncoupled to varying extents, releasing… CONTINUE READING
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