The many facets of PEDF in drug discovery and disease: a diamond in the rough or split personality disorder?

  title={The many facets of PEDF in drug discovery and disease: a diamond in the rough or split personality disorder?},
  author={Susan E Craword and Philip P Fitchev and Dorina Veliceasa and Olga V. Volpert},
  journal={Expert opinion on drug discovery},
  volume={8 7},
INTRODUCTION Pigment epithelium-derived factor (PEDF) was discovered as a neurotrophic factor secreted by retinal pigment epithelial cells. A decade later, it re-emerged as a powerful angiogenesis inhibitor guarding ocular function. Since then, significant advances were made identifying PEDF's mechanisms, targets and biomedical applications. AREAS COVERED The authors review several methodologies that have generated significant new information about the potential of PEDF as a drug. Furthermore… CONTINUE READING
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