The many facets of PEDF in drug discovery and disease: a diamond in the rough or split personality disorder?

@article{Craword2013TheMF,
  title={The many facets of PEDF in drug discovery and disease: a diamond in the rough or split personality disorder?},
  author={Susan E Craword and Philip P Fitchev and Dorina Veliceasa and Olga V. Volpert},
  journal={Expert opinion on drug discovery},
  year={2013},
  volume={8 7},
  pages={769-92}
}
INTRODUCTION Pigment epithelium-derived factor (PEDF) was discovered as a neurotrophic factor secreted by retinal pigment epithelial cells. A decade later, it re-emerged as a powerful angiogenesis inhibitor guarding ocular function. Since then, significant advances were made identifying PEDF's mechanisms, targets and biomedical applications. AREAS COVERED The authors review several methodologies that have generated significant new information about the potential of PEDF as a drug. Furthermore… CONTINUE READING
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Different expression of vascular endothelial growth factor and pigment epithelium-derived factor between diabetic and non-diabetic epiretinal membranes.

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde • 2009
View 7 Excerpts
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Pigment epithelium-derived factor (PEDF) ameliorates advanced glycation end product (AGE)-induced hepatic insulin resistance in vitro by suppressing Rac-1 activation.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme • 2008
View 5 Excerpts
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The neuroprotective and angiogenesis inhibitory serpin, PEDF: new insights into phylogeny, function, and signaling.

Frontiers in bioscience : a journal and virtual library • 2005
View 20 Excerpts
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