The many faces of redundancy in DNA replication control.

@article{Diffley2010TheMF,
  title={The many faces of redundancy in DNA replication control.},
  author={John F X Diffley},
  journal={Cold Spring Harbor symposia on quantitative biology},
  year={2010},
  volume={75},
  pages={135-42}
}
The large genomes of eukaryotic cells are replicated from multiple replication origins during S phase of the cell cycle. These origins are not activated synchronously at the beginning of S phase but, instead, fire throughout S phase according to a predetermined, cell-type-specific program. Ensuring that each origin is efficiently activated once and only once during each S phase is crucial for maintaining the integrity of the genome. This is achieved by a two-step mechanism. The first step… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Similar Papers

Loading similar papers…