The many faces of redundancy in DNA replication control.

  title={The many faces of redundancy in DNA replication control.},
  author={John F X Diffley},
  journal={Cold Spring Harbor symposia on quantitative biology},
The large genomes of eukaryotic cells are replicated from multiple replication origins during S phase of the cell cycle. These origins are not activated synchronously at the beginning of S phase but, instead, fire throughout S phase according to a predetermined, cell-type-specific program. Ensuring that each origin is efficiently activated once and only once during each S phase is crucial for maintaining the integrity of the genome. This is achieved by a two-step mechanism. The first step… CONTINUE READING

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