The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis.

  title={The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis.},
  author={Chiung-Chih Chang and Zena Werb},
  journal={Trends in cell biology},
  volume={11 11},
Metalloproteases are important in many aspects of biology, ranging from cell proliferation, differentiation and remodeling of the extracellular matrix (ECM) to vascularization and cell migration. These events occur several times during organogenesis in both normal development and during tumor progression. Mechanisms of metalloprotease action underlying these events include the proteolytic cleavage of growth factors so that they can become available to cells not in direct physical contact… CONTINUE READING

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