The many faces of CREB

@article{Carlezon2005TheMF,
  title={The many faces of CREB},
  author={William A. Carlezon and Ronald S. Duman and Eric J. Nestler},
  journal={Trends in Neurosciences},
  year={2005},
  volume={28},
  pages={436-445}
}
The transcription factor CREB is best known for its involvement in learning and memory. However, emerging evidence suggests that CREB activity has very different roles--sometimes beneficial, sometimes detrimental--depending on the brain region involved. Induction of CREB in the hippocampus by antidepressant treatments could contribute to their therapeutic efficacy. By contrast, activation of CREB in the nucleus accumbens and several other regions by drugs of abuse or stress mediates certain… Expand
CREB, neurogenesis and depression.
  • P. Gass, M. Riva
  • Biology, Medicine
  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2007
TLDR
This minireview tries to reconcile these new findings with established concepts on CREB, neurogenesis and depression, and outlines some crucial experiments and lines of future research that could clarify some of the pending questions. Expand
Effect of hippocampal CREB deletion on models of anxiety, depression, and antidepressant response
TLDR
Behavioral results suggest that CREB in the hippocampus may not be necessary for the behavioral response to antidepressants, challenging a previous study that suggested increased CREB activity was sufficient to produce an antidepressant behavioral response. Expand
Transcription Factors CREB and NF-KB: Involvement in Synaptic Plasticity and Memory Formation
TLDR
Interestingly, CREB activity is altered in some psychiatric disorder such as anxiety and depression, which suggest that this programme is essential for the correct functioning of the brain. Expand
The Role of CREB in Neuronal Plasticity, Learning and Memory, and in Neuropsychiatric Disorders
A characteristic of higher organisms is their ability to learn by experience in order to adapt their behaviour. Such plasticity is largely the result of the brain's ability to convert transientExpand
Inhibition of CREB Activity in the Dorsal Portion of the Striatum Potentiates Behavioral Responses to Drugs of Abuse
TLDR
It is shown that inhibition of striatal CREB facilitates cocaine- and morphine-place conditioning and enhances locomotor sensitization to cocaine, proposing CREB as a positive regulator of dorsal striatum-dependent procedural learning but a negative regulator of drug-related learning. Expand
The Nuclear Transcription Factor CREB: Involvement in Addiction, Deletion Models and Looking Forward
TLDR
Increasing evidence has supported a contribution of the nuclear transcription factor CREB in the development of addiction, both in contribution to phenotype and expression in brain regions critical to various aspects of drug-seeking behaviour and drug reward. Expand
Increased Hippocampal Neurogenesis and Accelerated Response to Antidepressants in Mice with Specific Deletion of CREB in the Hippocampus: Role of cAMP Response-Element Modulator τ
TLDR
Viral overexpression of the activator isoform of CREM, CREMτ, in the hippocampus resulted in an accelerated response to antidepressants as well as increased hippocampal neurogenesis, the first demonstration ofCREMτ within the brain playing a role in behavior and specifically in behavioral outcomes following antidepressant treatment. Expand
CREB-Dependent Transcription and Synaptic Plasticity
TLDR
This chapter describes how learning-related stimuli can activate signaling pathways that converge on the induction of CRE-driven gene expression and how the nuclear response orchestrated by CREB can alter future synaptic activity. Expand
CREB-mediated synaptogenesis and neurogenesis is crucial for the role of 5-HT1a receptors in modulating anxiety behaviors
TLDR
It is shown in mice that the transcription factor cAMP response element binding protein (CREB) in the hippocampus functions as an effector of 5-HT1aR in modulating anxiety-related behaviors, and suggests that CREB-mediated hippoacampus structural plasticity is crucial for the role of 4-HT2A-receptor in modifying anxiety- related behaviors. Expand
Role of the Transcription Factor CREB in the NMDA Receptor Antagonist-Induced Attention Deficits
This thesis is the result of a multidisciplinary approach which combines behavioral, biochemical and neurochemical assays to identify and delineate the molecular mechanisms involved in the control ofExpand
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TLDR
These experiments represent the first targeting of the dorsal hippocampus in genetically modified mice and confirm a role for CREB in hippocampus-dependent learning and suggest that some experimental forms of plasticity bypass the requirement forCREB. Expand
Modulation of Anxiety-Like Behavior and Morphine Dependence in CREB-Deficient Mice
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The results emphasize the selective role played by neuronal CREB in emotional-like behavior and the somatic expression morphine withdrawal, without participating in the rewarding properties induced by morphine and cocaine. Expand
Differential distribution of CREB in the mesolimbic dopamine reward pathway
TLDR
The distribution of CREB protein in the nucleus accumbens and ventral tegmental area is examined, two brain regions that are part of the well‐defined mesolimbic dopamine pathway involved in reward processing and demonstrate significantly more CRE binding activity and CREBprotein in the NAc compared to levels present in the VTA of wild‐type mice. Expand
Inducible repression of CREB function disrupts amygdala-dependent memory
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It is shown that lesioning or blocking protein synthesis in the basolateral amygdala of mice disrupts conditioned taste aversion and either chronically or acutely disrupting CREB function in two different types of genetically modified mice blocks memory for conditioned Taste aversion measured 24 h following training. Expand
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The results demonstrate that nucleus accumbens CREB–dynorphin influence behavior in the learned helplessness model and suggest that this signaling cascade may contribute to symptoms of depression. Expand
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TLDR
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Hurdles the authors believe may limit the usefulness of CREB per se as a target for the development of memory-enhancing drugs, and focus on components of the upstream signalling pathways or on specific downstream targets will be required. Expand
Regulation of Drug Reward by cAMP Response Element-Binding Protein: Evidence for Two Functionally Distinct Subregions of the Ventral Tegmental Area
TLDR
It is demonstrated that chronic exposure to drugs of abuse induces CREB activity throughout the ventral tegmental area of the VTA and two functionally distinct subregions of theVTA are established in which CREB differentially regulates drug reward. Expand
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TLDR
An intracellular cascade-culminating in gene expression-through which exposure to cocaine modifies subsequent responsiveness to the drug is identified. Expand
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