The many HATs of transcription coactivators.

@article{Brown2000TheMH,
  title={The many HATs of transcription coactivators.},
  author={Christine E Brown and Thomas Lechner and L Howe and Jerry L. Workman},
  journal={Trends in biochemical sciences},
  year={2000},
  volume={25 1},
  pages={15-9}
}
Histone acetylation is closely linked to gene transcription. The identification of histone acetyltransferases (HATs) and the large multiprotein complexes in which they reside has yielded important insights into how these enzymes regulate transcription. The demonstration that HAT complexes interact with sequence-specific activator proteins illustrates how these complexes target specific genes. In addition to histones, some HATs can acetylate non-histone proteins suggesting multiple roles for… CONTINUE READING

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