The mannose receptor on murine liver sinusoidal endothelial cells is the main denatured collagen clearance receptor

@article{Malovic2007TheMR,
  title={The mannose receptor on murine liver sinusoidal endothelial cells is the main denatured collagen clearance receptor},
  author={Ivana Malovic and Karen Kristine S{\o}rensen and Kjetil H Elvevold and Geir Ivar Nedredal and Steinar Martin Paulsen and Alexander V. Erofeev and B{\aa}rd Smedsr{\o}d and Peter McCourt},
  journal={Hepatology},
  year={2007},
  volume={45}
}
The purpose of this study was to identify the receptor responsible for endocytosis of denatured collagen from blood. The major site of clearance of this material (at least 0.5 g/day in humans) is a receptor on liver sinusoidal endothelial cells (LSECs). We have now identified an 180‐kDa endocytic receptor on LSECs, peptide mass fingerprinting of which revealed it to be the mannose receptor. Challenge of mannose‐receptor knockout mice and their cultured LSECs revealed significantly reduced blood… Expand
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