The mannose receptor

@article{MartnezPomares2012TheMR,
  title={The mannose receptor},
  author={Luisa Mart{\'i}nez-Pomares},
  journal={Journal of Leukocyte Biology},
  year={2012},
  volume={92}
}
The MR is a highly effective endocytic receptor with a broad binding specificity encompassing ligands of microbial and endogenous origin and a poorly characterized ability to modulate cellular activation. This review provides an update of the latest developments in the field. It discusses how MR biology might be affected by glycosylation and proteolytic processing, MR involvement in antigen delivery, and the potential contribution of MR to T cell differentiation and cellular activation. Further… 
Tumor cells express pauci- and oligomannosidic N-glycans in glycoproteins recognized by the mannose receptor (CD206).
TLDR
This study demonstrates that the MR CTLD4-7 is highly selective for pauci- and oligomannosidic N-glycans, structures that are often elevated in tumor cells, and suggest a potential role for the MR in tumor biology.
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TLDR
Surface plasmon resonance studies confirm that both mannose and lipid moieties play significant roles in receptor-mediated uptake on APCs, potentially facilitating vaccine development.
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The thesis is that macrophage specialization and functions go far beyond immunobiology, while remaining an essential contributor to innate as well as adaptive immunity.
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TLDR
This chapter focuses on only two families of lectins, the Siglecs and C-type lectins and provides a brief overview of each family and then highlights how these lectins can influence myeloid cell functioning in health and disease.
Targeting the C-type lectins-mediated host-pathogen interactions with dextran.
  • S. Pustylnikov, Divya Sagar, P. Jain, Zafar K. Khan
  • Biology, Medicine
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
  • 2014
TLDR
Dextran is considered a promising molecule for the development of lectin-glycan interaction-blocking molecules (such as DC-SIGN inhibitors) that could be applied in the treatment of diseases including tuberculosis, influenza, hepatitis B and C, human immunodeficiency virus infection and AIDS, etc.
Mannose receptor 1 expression does not determine the uptake of high-density mannose dendrimers by activated macrophages populations
TLDR
It is concluded that MRC1 expression does not determine the uptake of high-density mannose dendrimers and is suggested that 99mTc-HYNIC-dendrimer-mannose-Cy7 is not internalized via macrophage MRC 1.
A sweet spot for macrophages: focusing on polarization.
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TLDR
The role of the MR in innate host defense as well as the recent evidence for its role in the adaptive response, for both humoral and cellular immune responses are reviewed.
The Mannose Receptor Mediates Uptake of Soluble but Not of Cell-Associated Antigen for Cross-Presentation1
TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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