The mannose receptor

@article{MartnezPomares2012TheMR,
  title={The mannose receptor},
  author={Luisa Mart{\'i}nez-Pomares},
  journal={Journal of Leukocyte Biology},
  year={2012},
  volume={92}
}
The MR is a highly effective endocytic receptor with a broad binding specificity encompassing ligands of microbial and endogenous origin and a poorly characterized ability to modulate cellular activation. This review provides an update of the latest developments in the field. It discusses how MR biology might be affected by glycosylation and proteolytic processing, MR involvement in antigen delivery, and the potential contribution of MR to T cell differentiation and cellular activation. Further… Expand
Tumor cells express pauci- and oligomannosidic N-glycans in glycoproteins recognized by the mannose receptor (CD206).
TLDR
This study demonstrates that the MR CTLD4-7 is highly selective for pauci- and oligomannosidic N-glycans, structures that are often elevated in tumor cells, and suggest a potential role for the MR in tumor biology. Expand
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TLDR
The crystal structures of the N-terminal fragments of MR are determined and the potential binding mode of collagen on the fibronectin II domain is revealed, providing a model for the dynamic mechanism of MR regarding its ligand binding and release during the recycling between cell surface and endosomes. Expand
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TLDR
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TLDR
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TLDR
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  • S. Pustylnikov, Divya Sagar, P. Jain, Zafar K Khan
  • Biology, Medicine
  • Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
  • 2014
TLDR
Dextran is considered a promising molecule for the development of lectin-glycan interaction-blocking molecules (such as DC-SIGN inhibitors) that could be applied in the treatment of diseases including tuberculosis, influenza, hepatitis B and C, human immunodeficiency virus infection and AIDS, etc. Expand
A sweet spot for macrophages: focusing on polarization.
TLDR
Studies of the roles of glycosylation, glucose metabolism, and key lectins in the regulation of macrophages function and polarization are reviewed to provide a new perspective for immunotherapies for multiple diseases. Expand
Mannose receptor 1 expression does not determine the uptake of high-density mannose dendrimers by activated macrophages populations
TLDR
It is concluded that MRC1 expression does not determine the uptake of high-density mannose dendrimers and is suggested that 99mTc-HYNIC-dendrimer-mannose-Cy7 is not internalized via macrophage MRC 1. Expand
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The current knowledge regarding the different aspects of MR binding properties, contribution to homeostatic clearance, cell activation and antigen presentation are summarized. Expand
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TLDR
The mannose receptor functions in rapid internalization and concentration of a variety of glycosylated antigens that become available for processing and presentation, which may contribute to the unique capacity of dendritic cells to generate primary T cell responses against infectious agents. Expand
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