The mannose 6-phosphate/insulin-like growth factor II receptor restricts the tumourigenicity and invasiveness of squamous cell carcinoma cells.

@article{Probst2009TheM6,
  title={The mannose 6-phosphate/insulin-like growth factor II receptor restricts the tumourigenicity and invasiveness of squamous cell carcinoma cells.},
  author={Olivia C. Probst and Verena Puxbaum and Barbara Svoboda and Vladim{\'i}r Leksa and Hannes Stockinger and Mario Mikula and Wolfgang Mikulits and Luk{\'a}s Mach},
  journal={International journal of cancer},
  year={2009},
  volume={124 11},
  pages={2559-67}
}
The mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) mediates biosynthetic sorting and endocytosis of various factors that impinge on the proliferation, migration and invasiveness of tumour cells. The gene encoding M6P/IGF2R is frequently lost or mutated in a wide range of malignant tumours including squamous cell carcinomas. We have… CONTINUE READING