The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R), a putative breast tumor suppressor gene

@article{Oates1998TheM6,
  title={The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R), a putative breast tumor suppressor gene},
  author={Adam J. Oates and Lisa M. Schumaker and Sara B. Jenkins and Amelia A. Pearce and Stacey A. DaCosta and B. J. Arun and Matthew J. C. Ellis},
  journal={Breast Cancer Research and Treatment},
  year={1998},
  volume={47},
  pages={269-281}
}
Loss of heterozygosity (LOH) at the mannose 6-phosphate/insulin-like growth factor 2 receptor gene locus (M6P/IGF2R) on 6q26-27 has recently been demonstrated in approximately 30% of both invasive and in situ breast cancers. LOH was coupled with somatic point mutations in the remaining allele in several instances, leading to the proposition that M6P/IGF2R is a tumor suppressor gene [1]. Somatic mutations in M6P/IGF2R have also been described in hepatoma [2] and gastrointestinal cancers with the… CONTINUE READING