The manipulability of what? The history of G-protein coupled receptors

@article{Barwich2017TheMO,
  title={The manipulability of what? The history of G-protein coupled receptors},
  author={Ann-Sophie Barwich and Karim Bschir},
  journal={Biology \& Philosophy},
  year={2017},
  volume={32},
  pages={1317-1339}
}
This paper tells the story of G-protein coupled receptors (GPCRs), one of the most important scientific objects in contemporary biochemistry and molecular biology. By looking at how cell membrane receptors turned from a speculative concept into a central element in modern biochemistry over the past 40 years, we revisit the role of manipulability as a criterion for entity realism in wet-lab research. The central argument is that manipulability as a condition for reality becomes meaningful only… 
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References

SHOWING 1-10 OF 58 REFERENCES
Seven transmembrane receptors: something old, something new
TLDR
A very personal retrospective of research over the past 35 years which ultimately led to the identification, purification, reconstitution and cloning of the adrenergic receptors is provided.
“Receptive Substances”: John Newport Langley (1852–1925) and his Path to a Receptor Theory of Drug Action
TLDR
During the last twenty years the modern techniques of molecular biology have helped to determine the genetic basis of receptor proteins, to identify their amino acid sequences, and to further elucidate their remarkable structural diversity as well as their similarities and evolutionary relationships.
The structural basis of G-protein-coupled receptor signaling (Nobel Lecture).
TLDR
Given the central role played by GPCRs in nearly all physiologic processes, they represent the largest group of targets for drug discovery for a broad spectrum of diseases.
What is so special about smell? Olfaction as a model system in neurobiology
  • A. Barwich
  • Biology
    Postgraduate Medical Journal
  • 2015
TLDR
Research on the OR binding site investigates what amino acid sequences determine the receptor-binding capacity, and promises a better understanding of how the basic genetic makeup of GPCRs relates to their diversification in ligand-binding capacities.
The structure and function of G-protein-coupled receptors
G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a
G protein-coupled receptor rhodopsin.
TLDR
Evidence is provided of the propensity of rhodopsin and, most likely, other GPCRs to dimerize, a property that may be pertinent to their function.
Biographies of scientific objects
Why does an object or phenomenon become the subject of scientific inquiry? Why do some of these objects remain provocative, while others fade from centre stage? And why do objects sometimes return as
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
TLDR
The β2AR structure differs from rhodopsin in having weaker interactions between the cytoplasmic ends of transmembrane (TM)3 and TM6, involving the conserved E/DRY sequences, which may be responsible for the relatively high basal activity and structural instability of the β2 AR.
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