The manganese superoxide dismutase of Escherichia coli K-12 associates with DNA.

@article{Steinman1994TheMS,
  title={The manganese superoxide dismutase of Escherichia coli K-12 associates with DNA.},
  author={Howard M. Steinman and Louis Weinstein and M. Brenowitz},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 46},
  pages={28629-34}
}
Superoxide dismutases (SODs) are vital components in the resistance of aerobic organisms to the toxicity of oxygen. Escherichia coli contains two highly homologous cytoplasmic SODs, a manganese- and an iron-containing enzyme (MnSOD, FeSOD). We previously demonstrated that MnSOD and FeSOD have different physiological functions and that MnSOD is more effective in preventing oxidative damage to DNA. In this report, purified E. coli MnSOD was shown to bind nonspecifically to DNA by electrophoretic… CONTINUE READING

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