The management of colorectal liver metastases: Expanding the role of hepatic resection in the age of multimodal therapy.

@article{Chiappa2009TheMO,
  title={The management of colorectal liver metastases: Expanding the role of hepatic resection in the age of multimodal therapy.},
  author={Antonio C Chiappa and Masatoshi Makuuchi and Nikolaos J. Lygidakis and Andrew Paul Zbar and Geoffrey Chong and Emilio Bertani and Paul J. Sitzler and Roberto Biffi and Ugo Pace and Paolo Pietro Bianchi and Gianmarco Contino and Pasquale Misitano and Francesco Orsi and Lucia Travaini and Gianluca Trifir{\`o} and Maria Giulia Zampino and Nicola Fazio and Aron Goldhirsch and Bruno Andreoni},
  journal={Critical reviews in oncology/hematology},
  year={2009},
  volume={72 1},
  pages={
          65-75
        }
}
Colorectal cancer (CRC) caused nearly 204,000 deaths in Europe in 2004. Despite recent advances in the treatment of advanced disease, which include the incorporation of two new cytotoxic agents irinotecan and oxaliplatin into first-line regimens, the concept of planned sequential therapy involving three active agents during the course of a patient's treatment and the integrated use of targeted monoclonal antibodies, the 5-year survival rates for patients with advanced CRC remain unacceptably… CONTINUE READING
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