The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system.

@article{Roa2009TheMT,
  title={The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system.},
  author={Juan Roa and David Garc{\'i}a-Galiano and L P{\'e}rez Varela and Miguel {\'A}ngel S{\'a}nchez-Garrido and Rafael Pineda and Juan Manuel Castellano and Francisco Ru{\'i}z-Pino and Magdalena Romero and Elisabeth Aguilar and Miguel Lopez and Francisco X Gayt{\'a}n and Carlos Di{\'e}guez and Leonor Pinilla and Manuel Tena-Sempere},
  journal={Endocrinology},
  year={2009},
  volume={150 11},
  pages={5016-26}
}
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that operates as sensor of cellular energy status and effector for its coupling to cell growth and proliferation. At the hypothalamic arcuate nucleus, mTOR signaling has been recently proposed as transducer for leptin effects on energy homeostasis and food intake. However, whether central mTOR also participates in metabolic regulation of fertility remains unexplored. We provide herein evidence for the involvement of mTOR in… CONTINUE READING
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