The mammalian ionic environment dictates microbial susceptibility to antimicrobial defense peptides

@article{Dorschner2006TheMI,
  title={The mammalian ionic environment dictates microbial susceptibility to antimicrobial defense peptides},
  author={R. Dorschner and B. L{\'o}pez-Garcı́a and A. Peschel and D. Kraus and K. Morikawa and V. Nizet and R. Gallo},
  journal={The FASEB Journal},
  year={2006},
  volume={20},
  pages={35 - 42}
}
Antimicrobial peptides (AMPs) have been shown in animal and human systems to be effective natural antibiotics. However, it is unclear how they convey protection; they often appear inactive when assayed under culture conditions applied to synthetic antibiotics. This inactivation has been associated with loss of function in physiological concentrations of NaCl or serum. In this study we show that the balance of host ionic conditions dictate microbial sensitivity to AMPs. Carbonate is identified… Expand
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