The mammalian homologue of the novel peptide Bv8 is expressed in the central nervous system and supports neuronal survival by activating the MAP kinase/PI-3-kinase pathways.

@article{Melchiorri2001TheMH,
  title={The mammalian homologue of the novel peptide Bv8 is expressed in the central nervous system and supports neuronal survival by activating the MAP kinase/PI-3-kinase pathways.},
  author={Daniela Melchiorri and Valeria Bruno and Gilbert Besong and Richard Teke Ngomba and Laura Cuomo and Antonio De Blasi and Agata G. Copani and Cosima Maria Moschella and Marianna Storto and Ferdinando Nicoletti and G{\"u}nter Lepperdinger and Francesca Passarelli},
  journal={The European journal of neuroscience},
  year={2001},
  volume={13 9},
  pages={1694-702}
}
Previous studies have identified the mammalian homologue of Bv8 (mBv8), a small protein originally isolated from skin secretions of the frog, Bombina variegata. In situ hybridization showed that mBv8 RNA was widely expressed in the rodent CNS, with high levels being detected in layer II of the cerebral cortex, limbic regions, cerebellar Purkinje cells, and dorsal and ventral horns of the spinal cord. A similar pattern of distribution was found by examining the presence of mBv8 protein by… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

Similar Papers

Loading similar papers…