The mammalian anti-proliferative BTG/Tob protein family.

  title={The mammalian anti-proliferative BTG/Tob protein family.},
  author={G. Sebastiaan Winkler},
  journal={Journal of cellular physiology},
  volume={222 1},
The mammalian BTG/Tob family comprises six proteins (BTG1, BTG2/PC3/Tis21, BTG3/ANA, BTG4/PC3B, Tob1/Tob and Tob2), which regulate cell cycle progression in a variety of cell types. They are characterised by the conserved N-terminal domain spanning 104-106 amino acids. Recent biochemical and structural data indicate that the conserved BTG domain is a protein-protein interaction module, which is capable of binding to DNA-binding transcription factors as well as the paralogues CNOT7 (human Caf1… CONTINUE READING
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