The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells.

@article{Wang2004TheMZ,
  title={The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells.},
  author={Fudi Wang and Byung-Eun Kim and Michael J. Petris and David J Eide},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 49},
  pages={51433-41}
}
The mouse and human Zip5 proteins are members of the ZIP family of metal ion transporters. In this study, we present evidence that mouse Zip5 is a zinc uptake transporter that is specific for Zn(II) over other potential metal ion substrates. We also show that, unlike many other mammalian ZIP proteins, the endocytic removal of mZip5 from the plasma membrane is not triggered by zinc treatment. Thus, the activity of mZip5 does not appear to be down-regulated by zinc repletion. Zip5 expression is… CONTINUE READING

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