The mammalian ULK1 complex and autophagy initiation

  title={The mammalian ULK1 complex and autophagy initiation},
  author={Maria Zachari and Ian G Ganley},
  booktitle={Essays in biochemistry},
Autophagy is a vital lysosomal degradation pathway that serves as a quality control mechanism. It rids the cell of damaged, toxic or excess cellular components, which if left to persist could be detrimental to the cell. It also serves as a recycling pathway to maintain protein synthesis under starvation conditions. A key initial event in autophagy is formation of the autophagosome, a unique double-membrane organelle that engulfs the cytosolic cargo destined for degradation. This step is… CONTINUE READING
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