The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function

Abstract

TRIM-NHL proteins are conserved regulators of development and differentiation but their molecular function has remained largely elusive. Here, we report an as yet unrecognized activity for the mammalian TRIM-NHL protein TRIM71 as a repressor of mRNAs. We show that TRIM71 is associated with mRNAs and that it promotes translational repression and mRNA decay… (More)
DOI: 10.1093/nar/gks1032

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