The mammalian START domain protein family in lipid transport in health and disease.

@article{Clark2012TheMS,
  title={The mammalian START domain protein family in lipid transport in health and disease.},
  author={Barbara J. Clark},
  journal={The Journal of endocrinology},
  year={2012},
  volume={212 3},
  pages={257-75}
}
Lipid transfer proteins of the steroidogenic acute regulatory protein-related lipid transfer (START) domain family are defined by the presence of a conserved ∼210 amino acid sequence that folds into an α/β helix-grip structure forming a hydrophobic pocket for ligand binding. The mammalian START proteins bind diverse ligands, such as cholesterol, oxysterols, phospholipids, sphingolipids, and possibly fatty acids, and have putative roles in non-vesicular lipid transport, thioesterase enzymatic… CONTINUE READING

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