The mammalian AP-3 adaptor-like complex mediates the intracellular transport of lysosomal membrane glycoproteins.

@article{Borgne1998TheMA,
  title={The mammalian AP-3 adaptor-like complex mediates the intracellular transport of lysosomal membrane glycoproteins.},
  author={Roland Le Borgne and A Alconada and Ulrike Bauer and Bernard Hoflack},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 45},
  pages={29451-61}
}
In mammalian cells, the mannose 6-phosphate receptors (MPRs) and the lysosomal glycoproteins, lysosomal-associated membrane protein (LAMP) I, lysosomal integral membrane protein (LIMP) II, are directly transported from the trans-Golgi network to endosomes and lysosomes. While MPR traffic relies on the AP-1 adaptor complex, we report that proper targeting of LAMP I and LIMP II to lysosomes requires the AP-3 adaptor-like complex. Overexpression of these proteins, which contain either a tyrosine… CONTINUE READING
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