The malignant clone and the bone-marrow environment.

  title={The malignant clone and the bone-marrow environment.},
  author={Klaus Podar and Paul G Richardson and Teru Hideshima and Dharminder Chauhan and Kenneth C. Anderson},
  journal={Best practice & research. Clinical haematology},
  volume={20 4},
Multiple myeloma (MM) is characterized by the clonal expansion of monoclonal immunoglobulin-secreting plasma cells within the bone marrow (BM). It has become clear that the intimate reciprocal relationship between the tumor cell clone and the niches of the BM microenvironment plays a pivotal pathophysiologic role in MM. We and others have identified several new molecular targets and derived novel therapies which induce cytotoxicity against MM cells in the BM milieu, including thalidomide… CONTINUE READING
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