• DOI:10.1038/nature01722
Corpus ID: 4415259

The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes

@article{Skaletsky2003TheMR,
  title={The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes},
  author={H. Skaletsky and Tomoko Kuroda-Kawaguchi and P. Minx and Holland S. Cordum and L. Hillier and L. Brown and S. Repping and Tatyana Pyntikova and J. Ali and T. Bieri and A. Chinwalla and A. Delehaunty and Kim D. Delehaunty and H. Du and G. Fewell and L. Fulton and R. Fulton and Tina Graves and S. Hou and Philip Latrielle and S. Leonard and E. Mardis and R. Maupin and J. McPherson and T. Miner and W. Nash and Christine Nguyen and P. Ozersky and K. Pepin and Susan M. Rock and T. Rohlfing and K. Scott and B. Schultz and C. Strong and A. Tin-Wollam and S. Yang and R. Waterston and R. Wilson and S. Rozen and D. Page},
  journal={Nature},
  year={2003},
  volume={423},
  pages={825-837}
}

• H. Skaletsky, Tomoko Kuroda-Kawaguchi, +37 authors D. Page
• Published 2003
• Biology, Medicine
• Nature

The male-specific region of the Y chromosome, the MSY, differentiates the sexes and comprises 95% of the chromosome's length. Here, we report that the MSY is a mosaic of heterochromatic sequences and three classes of euchromatic sequences: X-transposed, X-degenerate and ampliconic. These classes contain all 156 known transcription units, which include 78 protein-coding genes that collectively encode 27 distinct proteins. The X-transposed sequences exhibit 99% identity to the X chromosome. The X… Expand

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